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Nature Reviews Molecular Cell Biology, 21 , 85100

Adverse Reactions in Patients with Obstructive Sleep Apnea ZEPBOUND was evaluated in 2 randomized, double-blind, placebo-controlled trials (Study 5 and Study 6) that included a total of 467 adult patients with moderate to severe OSA and obesity [see Clinical Studies (14.2)]

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It remains unclear whether metabolic states primarily drive epigenetic changes, or whether epigenetic mechanisms are the dominant regulators influencing cellular metabolism