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It is interesting to consider the parallels between these two synucleinopathies and cellular selective vulnerability (Alegre-Abarrategui et al., Oxidative Stress Failure of the antioxidant proteins regulating ROS levels, like superoxide dismutase (SOD) and glutathione (GSH), results in oxidative stress, which may have deleterious effects inside cells (Indo et al., 2015)