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Patients may not be good candidates if they have: Uncontrolled diabetes Bleeding disorders Severe spinal infection Allergy to injection medications Recent steroid use for other conditions A full medical evaluation ensures the injection is performed safely

Frequent comorbidities are rheumatological and cardiovascular in nature, in particular, psoriatic arthritis

Infection risk: Though the benzyl alcohol preservative inhibits bacterial growth in the vial, any lapse in sterility (dirty needle, etc.) can introduce pathogens

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For instance, one study initially fabricated sulfated carboxymethylcellulos and then employed them to modify electrospun poly(hydroxybutyrate)/gelatin fibers [216]