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Effects of ramipril and vitamin E on atherosclerosis: the study to evaluate carotid ultrasound changes in patients treated with ramipril and vitamin E (SECURE)

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We were looking at these rodent studies, and were like, these look really promising. And were doing the math on species conversions to figure out human doses. Nobody was under the illusion that what they were doing was definitively safe, he continued

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Enzyme stability The cyclic disulfide bond structure makes it less likely to be degraded by proteases in adipose tissue, prolonging the action time