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Therefore, this technology is widely used by researchers due to its simple design, high efficiency, and low cost-effectiveness [96, 98]

A recent study on acupuncture therapy found that it significantly reduced gastroduodenal injury, decreased the microbial abundance of the thick-walled phylum, and increased the abundance of the anaplasmosis phylum in the stomachs of mice (84)

In general, payload release occurs in the TME or after cellular internalization within endosomal/lysosomal compartments, and in some systems may further proceed following endosomal escape, thereby determining the cytosolic availability of the active degrader [184,185,186]

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