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2.1.2 NDDS developed based on different enzyme systems in the gastrointestinal tract The gastrointestinal tract harbors an intricate enzymatic network that functions as highly specialized molecular shears, cleaving chemical bonds in most pharmaceutical compounds and rendering them biologically inactive prior to reaching their target sites ( Chitosan is a linear polysaccharide formed by randomly distributed N-acetyl-D-glucosamine and D-glucosamine units connected by (14) glucoside bonds (Figure 2A)

Only 1% of oligosaccharides are absorbed and excreted unchanged in the urine

Non-enteric-coated preparations of VPA are rapidly and nearly completely absorbed from the gastrointestinal tract, with peak plasma concentrations occurring 14 hours after ingestion [12]

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While glucose is required for the N-glycosylation-mediated stabilization of SCAP, glutamine is necessary for the nuclear translocation of SREBP (90)