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Aldo-keto reductases protect metastatic melanoma from ER stress-independent ferroptosis

106 recently showed that ischaemic tissues accumulate succinate, which, during reperfusion, is oxidised by complex II, giving rise to RET that produces high levels of ROS, which cause extensive macromolecular damage and trigger cell death

The fabrication of hollow microneedles involves intricate techniques such as three-dimensional (3D) printing, drawing lithography, and etching, demanding exacting precision and attention to detail to ensure human safety and product efficacy 43 , 44

This creates a complex regulatory network that can result in both positive and negative feedback loops