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LC3 recruitment is inhibited in the Atg7 knockout mouse model, LAMP2 expression is lower, autolysosome formation is impaired, sperm cytoplasmic clearance and mitochondrial rearrangement are inhibited, and PDLIM1 accumulates owing to impaired clearance, disrupting the assembly of sperm flagella and resulting in blocked sperm formation, reduced sperm motility, and asthenospermia [60, 146]

In this context, the consideration of dose-dependent side effects, such as exacerbating breathing difficulties in obstructive sleep apnea patients, impaired blood glucose control when consumed with carbohydrate-rich meals, and an increased risk of nighttime falls due to drowsiness, especially in the elderly, is imperative [236,237,238]

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10.1038/sj.embor.embor918

Each capsule provides a precise 500 mcg of this product in a clean, simple base of microcrystalline cellulose and a vegetable capsule