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Bhatt HD, McClain SA, Lee HM, Zimmerman T, Deng J, Johnson F, Gu Y, Golub LM

Tacrolimus is a powerful immunosuppressant primarily used to prevent organ transplant rejection and treat certain autoimmune conditions

The ingredients could act through two possible ways: (a) biological mechanism-oriented by exerting anti-photodamage actions, namely the products resulting of the direct and oxidative damage of DNA, downregulation the expression of MMPs, and pro-inflammatory cytokines confirmed in in vitro studies in keratinocytes and fibroblasts and in vivo and ex vivo studies, and/or (b) clinical effects-oriented by softening the visible effects of the skin sun damage, by providing moisturizing effect and refreshing properties, mainly corroborated by clinical trials

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[44] It has been reported that marine yeasts are able to produce many bioactive substances, such as amino acids, glucans, glutathione, toxins, enzymes, phytase, and vitamins with potential applications in the food, pharmaceutical, cosmetic, and chemical industries as well as for marine culture and environmental protection