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When G6PD is inhibited in murine cells both in vivo using 6-AN or knockdown, or in vitro using 6-AN or a novel selective small molecule inhibitor of G6PD (G6PDi-1), efferocytosis of apoptotic cells is significantly diminished 107,108,109

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2013 Jul;57-58:509

This is because DHODH, which catalyzes a crucial step in intracellular de novo pyrimidine biosynthesis (conversion of dihydroorotate to orotate), needs CoQ as a cofactor (FIGURE 3)