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In addition, the weak Nrf2-related antioxidant system in Tregs transforms them into apoptotic Tregs in oxidized TME, which can self-supply and release ATP, and convert it to adenosine to mediate, sustain, and amplify powerful suppression in the TME (84) 3.2.2 DCs DCs are fundamental for the initiation and maintenance of immune responses against cancer cells and have been shown to generate ROS during antigen presentation (87, 88)

This in turn leads to the deacetylation of Malate dehydrogenase 2 (MDH2) promoting mitochondrial fusion

C., & Giovannucci, E

Seiberg, M

Sex-specific expression of gastrin-releasing peptide receptor: relationship to smoking history and risk of lung cancer