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High constitutive investment in carbon-intensive defenses is frequently associated with reduced growth rates or delayed reproduction under low-stress conditions, consistent with classical growthdefense trade-off theory (Herms and Mattson, 1992)

Discontinue use if irritation occurs and persists

Although controversy remains over whether KD should be used to treat cancer, therapies that slow or stop cancer growth in early stages, use a broad-spectrum approach, target many signaling pathways, prevent cancer comorbidities such as cachexia and obesity, and have fewer adverse effects are very appealing

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