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Zn promotes the expression of ZFPs with anti-inflammatory properties, such as A20, which hinders the activity of NF- and NF- target genes, such as IL-1 and TNF, and thus prevents TNF-induced programmed cell death (113, 114)

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Elevated calcium also increases the risk of blood vessel calcification and heart disease

In summary, the DNA methylation and DNA demethylation modification of NRF2 plays a critical role in regulating its expression and function

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