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Risk increases significantly after 2+ years of use Post-bariatric surgery patients gastric bypass removes or bypasses the sites of intrinsic factor production and B12 absorption People with autoimmune conditions pernicious anemia (anti-intrinsic factor antibodies) and autoimmune gastritis directly block absorption People with GI conditions Crohns disease (especially ileal involvement), celiac disease, SIBO, and chronic H

When molecule-specific mixing data are unavailable, gentle mixing that avoids foam offers a conservative starting point for laboratory work

Some promising trends indicate more diverse trial enrollment in trials resulting in FDA approval as well as different diversity profiles of trials sponsored by NIH institutes/centers

Heart patients with high blood pressure should be aware of this possibility

The American Academy of Pediatrics reported more than 325,000 cases in children at the end of 2021