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however, it can also affect peripheral nerve fibers

Pain as an Integral Component of Wound Pathophysiology Regardless of the underlying cause, every wound is associated with varying degrees of pain, defined as an unpleasant sensory and emotional experience associated with, or pretending to be associated with, actual or potential tissue damage [30]

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Guyer RD: Stenosis in the Elderly: to Fuse or Not

Ranging from oxidative stress, and microglial activation to even apoptosis of neurons