levels of oxidized glutathione Reduced and (GSH, GSSG) and GSH/GSSG ratios Reduced (GSH) and oxidized (GSSG)

Various other potential antitumor compounds, including 2-methoxy-6-acetyl-7-methyljuglone [255], chlorpyrifos (an organophosphate pesticide) [260], and FTY720 (a sphingosine-1-phosphate receptor modulator) [259], have been found to exert cytotoxic effects on various GBM cancer cells by targeting NQO1

doi: 10.1002/iub.2411 150 KamachiKUreshinoHWatanabeTYoshida-SakaiNFukuda-KurahashiYKawasoeKet al

) through reduced nicotinamide adenine dinucleotide phosphate (NADPH) oxidase pathway which causes oxidative stress in lung via increasing lipid peroxidation of membrane lipid (Harijith et al

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