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Urolithin a (Ua) attenuates ferroptosis in lps-induced acute lung injury in mice by upregulating keap1-nrf2/ho-1 signaling pathway

Graphical Abstract Similar content being viewed by others Abbreviations 4-HNE: 4-Hydroxynonenal ac4C: N 4 -acetylcytidine AIFM2: Apoptosis-inducing factor mitochondria-associated 2 (synonym for FSP1) BRCA: Breast cancer gene ESCRT-III: Endosomal sorting complex required for transport III CHMP5/6: Charged multivesicular body protein 5/6 (ESCRT-III subunits) CoQ10: Coenzyme Q10 (ubiquinone-10) CoQH2: Ubiquinol (reduced form of CoQ10) DAMPs: Damage-associated molecular patterns DHODH: Dihydroorotate dehydrogenase FEZF1-AS1: FEZ family zinc finger 1 antisense RNA 1 FSP1: Ferroptosis suppressor protein 1 GAPLINC: Gastric adenocarcinoma predictive long intergenic noncoding RNA GPX4: Glutathione peroxidase 4 GSH: Glutathione HCC: Hepatocellular carcinoma HIF-1: Hypoxia-inducible factor 1 IHC: Immunohistochemistry ICD: Immunogenic cell death FSEN1: Ferroptosis sensitizer 1 iFSP1/icFSP1: Inhibitor of FSP1/inducer of condensation of FSP1 (specific inhibitor names) KRAS: Kirsten rat sarcoma viral oncogene homolog KEAP1: Kelch-like ECH-associated protein 1 LINK-A: Long intergenic noncoding RNA for kinase activation LLPS: Liquidliquid phase separation lncRNA: Long noncoding RNA MDA: Malondialdehyde METTL3: Methyltransferase 3 m 6 A: N 6 -methyladenosine miRNA/miR: MicroRNA MAPK: Mitogen-activated protein kinase NAT10: N -acetyltransferase 10 NAD(P)H: Nicotinamide adenine dinucleotide (phosphate) NMT: N -myristoyltransferase NRF2: Nuclear factor erythroid 2related factor 2 OGD/R: Oxygenglucose deprivation/reoxygenation PD-1/PD-L1: Programmed cell death protein 1/programmed death-ligand 1 SP1: Specificity protein 1 (transcription factor) TAMs: Tumor-associated macrophages TNBC: Triple-negative breast cancer TME: Tumor microenvironment TRIM21: Tripartite motif-containing protein 21 (E3 ubiquitin ligase) VKH2: Vitamin K hydroquinone Acknowledgements The graphical abstract and all schematic figures in this manuscript were created with BioRender.com

Nature 402(6762): 656-660

LES SECRETS DE LOLY Les Secrets de Loly Kurl Nectar Crme sans

For example, MT attenuates fungal infections in cotton (Li et al., 2019a) and enhances resistance to yellow wilt by influencing lignin and cotton phenol synthesis genes in the phenylpropane, MVA, and cotton phenol pathways