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It is involved in the transcription of genes that are essential for the development and function of the nervous system

CHOP is a critical regulator of acetaminophen-induced hepatotoxicity

Chronic kidney disease and NLRP3 inflammasome: pathogenesis, development and targeted therapeutic strategies

(2) Interestingly, it appears to achieve that by activating Erk5 and Erk1/2 while only weakly and transiently engaging Akt, and it may do so without detectable IGF-1 receptor tyrosine phosphorylation