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Oxidative Stress Is Not the Primary Mediator of Disease Pathology While tissue injury often increases ROS production and contributes to further damage, the primary pathological driver may not be oxidative stress, as it occurs in many cases secondary to other initiating factors (Figure 7)

[DOI] [PubMed] [Google Scholar] 126.Bonetti, A., Tugnoli, B., Piva, A

Mitochondrial dysfunction in endothelial cells, macrophages, and VSMCs plays a key role in plaque formation during atherosclerosis

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Safety Toxicity No toxic or adverse effects have been associated with large intakes of vitamin B 12 from food or supplements in healthy people