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However, developing engineered microbes as live biotherapeutic products presents considerable challenges in regulatory affairs, manufacturing, genetic stability, biocontainment, delivery, engraftment, and overall safety (135)

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Therefore, although both nonenzymatic and enzymatic succinylations occur on GCLC, the latter mediated by P300, in cooperation with SIRT2, may play a major role in dynamically modulating the succinylation level of GCLC under stress condition

[DOI] [PubMed] [Google Scholar] Lange SC, Bak LK, Waagepetersen HS, Schousboe A, Norenberg MD

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