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However, it is important to understand that animal research does not automatically translate to long-term safety in humans

Researchers modeling repeat-dose experiments generally aim to reach steady-state concentrations after four to five half-lives of continuous administration

doi: 10.3390/ph12010026 79

E., Saper, C

The full effects of these fat-soluble antioxidants can be demonstrated only when antioxidan tconcentrations are adjusted for the levels of LDL for individual subjects