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doi: 10.1111/j.1365-2796.2009.02207.x 75

14.2 Obstructive Sleep Apnea Studies in Adults with Obesity Overview of Study 5 and Study 6 The efficacy of ZEPBOUND for moderate to severe obstructive sleep apnea (OSA) (apnea-hypopnea index [AHI] 15) in patients with obesity (BMI 30 kg/m2) was evaluated in a master protocol clinical trial (NCT05412004) that included two randomized, double-blind, placebo-controlled trials (Study 5 and Study 6) of 52 weeks duration

Levothyroxine injections bypass the intestinal tract entirely, which solves the absorption problems that make oral levothyroxine ineffective for many thyroid patients

The mechanism of action is due to the fact that Larazotide acts as an antagonist against zonulin, which is a protein in the small intestine that affects gut permeability