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Ghigo, E., Arvat, E., Gianotti, L., Imbimbo, B

Signorelli, S

Plasmid for single-stranded adeno-associated viral vectors 2/8 The plasmid pAAV-MCS-hAAT/EGFP was designed for maximum transgene expression and includes the hepatic locus control region from the ApoE gene (ApoE-HCR), a liver-specific 1-antitrypsin promoter (hAAT promoter), coagulation factor IX intron A (FIX intron A), a 3' mRNA transcription termination/polyadenylation signal (bghpA), and a reporter gene encoding enhanced green fluorescent protein (EGFP), as previously described (Miao et al

Nonalcoholic steatohepatitis (NASH) patients have reduced levels of choline in the liver

The normal LSA is 4 o and LSA for mild LBP is 43 6.3, LSA for moderate LBP is 40 8.5 and LSA for severe LBP is 38 9.1 o