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Following incubation, the cells underwent three washes with PBS

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In contrast, at higher concentrations, curcumin may penetrate the bilayer and interact with acyl chains, increasing membrane fluidity and, consequently, water permeability [72]

Interventions such as the antioxidant NAC or the inhibition of MAPK8/JNK activity have been demonstrated to mitigate ROS-induced parthanatos in glioma cells [156], suggesting that MAPK8 activation contributes to parthanatos by enhancing intracellular ROS levels