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concentrations such as, but not limited to, 2 % (w/w), 3% (w/w), 4% (w/w), 5% (w/w), 6% (w/w), 7% (w/w), 8% (w/w), 9% (w/w), 10% (w/w), 11% (w/w), 12 % ( the pharmaceutical formulation may include one or more lipids and/or phospholipids at concentrations such as, but not limited to, 8.1 % (w/w), 8.2% (w/w), 8.3% (w/w), 8.4% (w/w), 8.5% (w/w), 8.6% (w/w), 8.7% (w/w), 8.8% (w/w), and/or 8.9% (w/w)

Enzymatic antioxidants have been highlighted as relevant to oxidative balance in therapy dogs, with supplementation outcomes varying by the specific enzymes and their activity levels (Sechi S, 2017)

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Ethics declarations Ethics approval and consent to participate The experimental procedures in this study were approved by the Ethics Committee of the Reproductive Hospital affiliated with Shandong University (Approval number:2022-73)

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