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Collectively, this approach was designed to provide a comprehensive, balanced, and mechanistically coherent synthesis of the existing evidence, while acknowledging variability in study quality, extract standardization, and clinical methodology across the literature

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The moderately negative zeta potential of the nanoparticles indicates partial electrostatic repulsion, which helps reduce aggregation and maintain dispersion in the medium

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146 Hypoglossal nerve stimulation may be helpful for individuals with obstructive sleep apnea who fail to respond to CPAP, and greater improvements in AHI can be expected for those with more severe disease, older age, and lower BMI