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of course, ascertainment is difficult if the characteristic clinical dyad of hemolytic anemia and metabolic acidosis is not recognized and urine organic acid studies are not obtained

The mutation analyses could be interpreted as heterozygous, homozygous or compound heterozygous without additional PCR runs since the wild type probes have been incorporated into the test kit for comparison

Hemolytic anemia was reported to be significantly more severe with G6PD Mediterranean and Cairo compared to G6PD A-, indicating a direct positive correlation between enzyme deficiency and severity of clinical manifestations

On the other hand, fibrosis may contribute to oxidative stress or both of them may be triggered by an independent mechanism