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Cancer cell-derived 12(S)-HETE signals via 12-HETE receptor, RHO, ROCK and MLC2 to induce lymph endothelial barrier breaching

Nat Rev Genet 18:164179

Because of the decrease in eosinophils, mepolizumab and reslizumab improve the symptoms of severe asthma, they provide significant and clinically relevant improvements in exacerbation rate and oral corticosteroid (OCS) reduction, thus greatly improve the clinical treatment of asthma (99)