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Jane Wilde, Consultant Dermatologist, London Results vary by skin type

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Abbreviations CO: Carbon monoxide DNA: Deoxyribonucleic acid GPx: Glutathione peroxidase GSH: Reduced glutathione GSSeH: Glutathioselenol GSSeSG: Selenodiglutathione H 2 O 2 : Hydrogen peroxide H 2 S: Hydrogen sulfide (gas) H 2 Se: Hydrogen selenide (gas) HS - : Hydrosulfide anion HSe - : Hydroselenide anion IL: Interleukin LDL: Low-density lipoprotein LPS: Lipopolysaccharide mRNA: Messenger ribonucleic acid Msr: Methionine sulfoxide reductase NaHSe: Sodium hydrogen selenide NF-B: Nuclear factor kappa B NO: Nitric oxide NTIS: Non-thyroidal illness syndrome ROS: Reactive oxygen species Se: Selenium SCL: Selenocysteine -lyase SeO 3 2- : Selenite SeO 4 2- : Selenate T3: Triiodothyronine T4: Thyroxine TNF-: Tumour necrosis factor alpha tRNA: Transfer ribonucleic acid Trx: Thioredoxin TrxR: Thioredoxin reductase TSH: Thyroid stimulating hormone References National Research Council (1983) Selenium in nutrition: Revised Edition

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All enrolled patients provided a medical history that included information on smoking and potential exposure to inhaled antigens and underwent a medical examination that involved: a chest X-ray, HRCT of the chest, pulmonary function tests, and bronchoscopy with bronchoalveolar lavage (BAL)