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Gene ontology (GO) functional annotation analysis of the 2,699 genes differentially expressed in response to B12 ( Figure S3 ) indicate that, in leukocytes of patients with moderate COVID-19, the vitamin stimulates the antiviral response induced by IFNs, regulates the exacerbated immune response induced by NF-kappaB and favors the inhibition of gene expression

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Understanding these causes is essential for appropriate clinical management and avoiding unnecessary alarm