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Importantly, although several PROTACs have advanced into clinical evaluation, their exact plasma membrane permeation mechanisms remain incompletely defined

In addition, both preclinical and clinical literature often underrepresent females, limiting insights into sex-specific immunometabolic and hormonal modulators of treatment response (Seyedinia et al., 2023

However some women prefer to either manage their symptoms or treat the insulin resistance at the root cause with lifestyle changes such as a healthy diet , exercise and supplements rather than medications

Healthy eating habits, portion control, and regular physical activity are crucial components of achieving and maintaining weight loss