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For instance, gene editing technologies like CRISPR-Cas9 present exciting possibilities for addressing age-related diseases, but concerns regarding off-target effects, long-term safety, and the ethical implications of genetic modifications need to be thoroughly addressed before such interventions can become mainstream (Caobi et al., 2020)

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In contrast, females do not exhibit this cytosolic inhibitory response and show impaired regulation of GR nuclear translocation, associated with disorganized localization of FKBP51, which becomes predominantly nuclear (Palumbo et al., 2020)