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Previously, CA structure was concluded as 1,3,4,5-tetrahydroxycyclohexane-1-carboxylic acid (Sprecher and Sprinson, 1963)

5.3 Tryptophan metabolites Tryptophan metabolites are generated either through direct decomposition of tryptophan by gut microbiota (e.g., Clostridium, Escherichia coli ) into indole derivatives (such as IPA and indole-3-acetic acid (IAA)) or via host-cell-mediated processes (e.g., indoleamine 2,3-dioxygenase 1(IDO1)-catalyzed kynurenine production, 5-hydroxytryptamine (5-HT) synthesis by enterochromaffin cells) in coordination with microbial metabolism

Response to Vitamin B12 and Folic Acid in Myalgic Encephalomyelitis and Fibromyalgia

doi:10.1007/978-3-540-69441-0_18 78 Schmidt JJ, Hafer C, Spielmann J, et al