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Histamine also has a circadian rhythm and is what keeps us awake

However, certain medications can affect B12 absorption, including metformin (used for diabetes), proton pump inhibitors, H2-receptor antagonists, and colchicine

This is a crucial biochemical reaction involved in: DNA synthesis Gene regulation Neurotransmitter production B12 acts as a coenzyme in this process

(the New York Times) - behind the Headlines - NLM. NCBI, www.ncbi.nlm.nih.gov/search/research-news/8501/