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Human effector CD8+ t cells derived from naive rather than memory subsets possess superior traits for adoptive immunotherapy

Succinate is an inflammatory signal that induces IL-1beta through HIF-1alpha

Results are intended for preliminary rapid screening and are meant to be confirmed using standard laboratory methods, consistent with established practices for point-of-care testing

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POLE and POLD1 mutations may be associated with MMR-D in some cases due to MMR mutations secondary to the hypermutator phenotype [60,61,63,64,65]