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Description

In DISC1 animal models, mice with point mutations in the gene or truncated forms of DISC1 display molecular, cellular, and behavioral phenotypes that are analogous to schizophrenia

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For instance, PINK1 and PARKIN mutations are common causes of autosomal recessive familial PD

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Modifications: Strategic amino acid substitutions enhance stability against enzymatic degradation (particularly by DPP-IV)

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The mechanisms do not appear to contradict each other, and some researchers have speculated that combining them could address both appetite and direct fat cell metabolism

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