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R152 and active site residues C46, K48, Q81, and W136 are highlighted and shown as sticks

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*Correspondence: Lei Xu, [email protected] Liu, [email protected] These authors have contributed equally to this work This article was submitted to Cellular Neuropathology, a section of the journal Frontiers in Cellular Neuroscience Disclaimer All claims expressed in this article are solely those of the authors and do not necessarily represent those of their affiliated organizations, or those of the publisher, the editors and the reviewers

Most likely, the underlying cause of drug resistance and treatment failure is metabolic reprogramming (25)

Because the general population is getting older, AMD is becoming more and more prevalent, and experts believe it will become even more common in the years to come