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Mechanisms range from effects on neurotransmitter systems to reduction of oxidative stress, to increased neurotrophic factors like BDNF, to enhanced cerebral blood flow

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Future research could integrate structural prediction technologies (e.g., AlphaFold-Multimer) with proteomics data to screen or design peptide analogs with multifunctional capabilities, such as neural guidance, angiogenesis, and immunomodulation, thereby constructing a synergistic glycopeptide hydrogel platform

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Bisubstrate inhibitors such as NS1, LL320, and II399 based on adenosyl scaffolds have shown promise in this regard 199201