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and 3) the absence of correlation between genotype and phenotype does not allow a prognosis to be made or change the approach to follow-up.62,63 Set against this opinion is the day-to-day reality of physicians who attend children with NF1: worried parents (who are perfectly informed about the risks and worst aspects of the disease) who want to know for sure whether their child has the disease

Hoang TT, Qi C, Paul KC, Lee M, White JD, Richards M, Auerbach SS, Long S, Shrestha S, Wang T, Beane Freeman LE, Hofmann JN, Parks C, Xu CJ, Ritz B, Koppelman GH, London SJ

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