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As cheeses and yogurts have shown more enhanced health benefits than regular milk, it has been proposed that fermentation plays a rolehighlighting the need for dietary guidelines to differentiate between fermented and non-fermented dairy products and further exploring the underlying metabolic mechanisms (14)

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The characteristic hypermethylation within promoter regions of colorectal cancer tumor suppressor genes indicates that the epigenome likely plays a key role in mediating non-genetic sequence modifications driving malignant phenotype (182)