melanotic sarcoma skin cancer Melanoma Rare Skin Cancers

Peer review Peer review information Nature Reviews Gastroenterology & Hepatology thanks Alberto Camineo, Sunny Hei Wong and Bahtiyar Yilmaz for their contribution to the peer review of this work

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Estrogens play a major role in enhancing the GH response to GHSs at puberty, which GHRH hypoactivity, somatostatinergic hyperactivity and impaired activity of the putative GHS-like ligand and receptors probably explain the reduced GH-releasing effect of GHSs in aging

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Central to their responses is the modulation of redox status, where the equilibrium between the generation of reactive oxygen species (ROS) and antioxidant defense plays a critical role