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5b, the red fluorescence indicative of O 2 levels in Raw 264.7 cells was particularly strong when treated with PBS and PBS + laser (808 nm, 1 W/cm 2 )

8 When APAP is administered at therapeutic doses under normal physiological conditions, the remaining 510% of the drug is metabolized in hepatocytes by cytochrome P450 enzymes such as CYP2E1 and CYP1A2 through phase I enzymatic reactions, resulting in the generation of the toxic reactive metabolite NAPQI (Fig