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Indeed, the United States Food and Drug Administration and the (United States) National Institutes of Health have recognized the need for updated approaches to the licensing of RBC products that incentivize the goal of improved clinical benefits in anemic patients receiving transfusion ( Red Blood Cell Storage Duration and Trauma Retrospective studies had indicated an increased risk of poorer outcomes following transfusion with longer-stored RBCs in trauma, ICU, and cardiac surgery patients

Biochemical and Biophysical Research Communications, 530(1), 222-229

This drives unchecked proliferation of myeloid lineages, predominantly erythrocytes, leading to the markedly elevated hemoglobin and hematocrit seen in this patient, along with a concurrent mild elevation in platelets

SR101) (5 M

After incubation, the cells were examined and imaged using a fluorescence microscope (ECLIPSE Ti2