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The study of drug metabolism is one of the tenets of pharmacokinetics (PK) as metabolism (M), the fourth stage of LADME (a drug's transit through the body), involves the enzymatic biotransformation and non-enzymatic biotransformation of a drug, thereby leading to the fifth stage, excretion (E)

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Irrespective of the location and source of GrK in vivo , GrK protein could potentially be therapeutically administered in tumors to trigger sVEGFR1 release from endothelial cells to impair angiogenesis and tumor growth

Pixel quantification of images was achieved using Image J and statistics were performed using Prism 5 and InStat v.3.05