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Eur Respir J 9:632633 Flinn AM, Gennery AR (2018) Adenosine deaminase deficiency: a review

19,26,27,28 After recognition of the AP-MHC class II complex and T-cell receptor (TCR), CD4 + T cells distributed in peripheral lymphoid organs can differentiate into Th1 cells, which secrete various cytokines, such as interleukin 2 (IL-2), and simultaneously upregulate the expression of related receptors (IL-2R)