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Methylmalonic acid and the microbiome Emerging evidence suggests that circulating levels of MMA can be shaped by the gut microbiome, complicating their use as a straightforward biomarker of B12 deficiency in clinical settings

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In fact, the expression of those genes was lowered to levels similar to those of acne patients." So it looks like by intaking extra vitamin B12, we could be prompting the bacteria in our skin to slow down on their production of it, which leads to an imbalance that could heighten our risk of developing acne

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[14] When taken orally, L-Carnitine requires a high dose to promote fat tissue breakdown