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Moreover, other terpenes were found to effectively inhibit necroptosis/apoptosis/ferroptosis and conferr protection against AP, such as celastrol (Liang et al., 2023), crocetin (Zhu and He, 2022), and glycyrrhizin (Xia et al., 2021) and astaxanthin (Kwak et al., 2021)] exert pancreatic protection by suppressing JAK2/STAT3 hyperactivation, thereby reducing pro-inflammatory cytokine production

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Additionally, curcumin stimulated the activation of MAPK pathway which in turn induced the expression of heterodimers of NF-E2-related factors 2 (Nrf2) that is responsible for ARE activation reporter genes [268]

24 25 Some patients may experience recurrence or worsening of symptoms when the interval between injections is extended or extended too quickly, and report that continuation of frequent intramuscular hydroxocobalamin injections, varying between twice weekly and once every three to four weeks, 65 is needed to remain asymptomatic