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Disruption of gut barrier integrity may facilitate the translocation of metabolites such as short-chain fatty acids (SCFAs), bile acids, tryptophan derivatives, and lipopolysaccharide (LPS), which can modulate BBB function and neuroinflammatory responses [122]

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Nat Rev Neurol 19:278288

Koinuma D, Tsutsumi S, Kamimura N, Taniguchi H, Miyazawa K, Sunamura M, Imamura T, Miyazono K, Aburatani H: Chromatin immunoprecipitation on microarray analysis of Smad2/3 binding sites reveals roles of ETS1 and TFAP2A in transforming growth factor beta signaling