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It has been demonstrated to induce mitochondrial damage and both intrinsic apoptotic and mPTP-driven cell death 13,14,15,16 via signalling pathways, indicating that its mode of action may involve BAX and BAK1

After 6 days of intravenous injection of recombinant AIMP1 in a mouse xenograft model bearing human stomach cancer cells, the tumor volume and weight decreased significantly 102

This bead-binding assay was used to quantitate the binding of scFv to MHC complexes with alanine-scan substitutions of the PHOX2B peptides and to a plate of 95 unrelated 9-amino-acid peptide A*24:02MHC complexes

Very recently, two families, each with two affected siblings, were reported

[DOI] [PMC free article] [PubMed] [Google Scholar] 41.Lv J., Xiong X