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Loss of C9orf72 during starvation leads to dysregulated autophagy and increased de novo fatty acid synthesis (Liu Y

Specifically, the indirect mechanism is chelation of transition metals, which prevents participation within the Haber-Weiss (Kehrer, 2000) or Fenton reaction, while the direct mechanism involves donating or receiving of electrons, scavenging radicals, and consequently preventing their reaction with biological molecules